ABSTRACT
Abstract Our aim was to investigate if single nucleotide polymorphisms (SNPs) located in the 5′ regions of leptin (LEP, -2548 G > A, rs7799039), resistin (RETN, -420 C > G, rs1862513) and adiponectin (ADIPOQ, -11391 G > A, rs17300539 and -11377 C > G, rs266729) genes were related to changes in body mass index (BMI) and metabolic variables after bariatric surgery in 60 extremely obese individuals. At baseline, ADIPOQ -11391 A-allele carriers showed higher plasma adiponectin and lower total cholesterol levels when compared to G/G homozygotes. Approximately 32 months post-surgery, a mean reduction of 35% in BMI and an important improvement in metabolic profiles were observed. In addition, for the ADIPOQ -11377 polymorphism, a higher decrease in lipid profile was associated to the C/C genotype. Moreover, individuals bearing the A-C haplotype for the two ADIPOQ SNPs were more prone to show a reduction in low-density lipoprotein levels after bariatric surgery (-43.0% A-C carriers vs. -18.1% G-G carriers, p = 0.019). We did not find any association of leptin and resistin SNPs with the clinical parameters analyzed. In summary, our results indicate that the A-C haplotype is a predictor of better lipid profile post-surgery and the studied SNPs in ADIPOQ gene are associated to changes in metabolic variables in obese individuals.
ABSTRACT
OBJETIVO: Aferir complicações pós-operatórias imediatas e tardias em pacientes portadores de hérnia inguinal, submetidos à correção cirúrgica pela técnica de Gilbert1, com utilização do Sistema Prolene de Hérnia (SPH). MÉTODOS: Foram pesquisados todos os pacientes submetidos à herniorrafia inguinal com tela PHS no Hospital São Lucas da PUCRS no período de janeiro de 2001 até ourubro de 2006. As informações foram coletadas de modo retrospectivo, através de contato telefônico e revisão de prontuários. O protocolo de coleta de dados contemplou os aspectos epidemiológicos, bem como as complicações imediatas e tardias. RESULTADOS: Foram incluídos 96 pacientes. Foram identificadas seis (6,25 por cento) complicações, em pacientes distintos; nenhuma complicação com óbito. Dois pacientes (2,08 por cento) apresentaram seroma; hematoma foi identificado em um paciente (1,04 por cento); um paciente (1,04 por cento) apresentou infecção de ferida operatória. Dois pacientes (2,08 por cento) apresentaram edema escrotal. Após seguimento médio de 49,25 meses (16-86,12) dois pacientes (2,08 por cento) apresentaram dor crônica e um paciente (1,04 por cento) apresentou recorrência, com vinte e seis meses de pós-operatório. CONCLUSÃO: O reparo de hérnias inguinais com tela PHS é um método seguro, eficaz, facilmente reprodutível e com baixas taxas de complicações, recorrência ou sintomas em longo prazo.
OBJECTIVE: To assess immediate postoperative and late complications in patients with inguinal hernia undergoing surgical correction by Gilbert¹ technique, using the Prolene Hernia System (HPS). METHODS: We surveyed all patients undergoing inguinal hernia repair with PHS mesh at The Sao Lucas Hospital - PUCRS, from January 2001 to october 2006. Information was retrospectively collected through telephone calls and chart review. The protocol for data collection included epidemiological aspects, as well as immediate and late complications. RESULTS: ninety-six patients were enrolled. We identified six (6.25 percent) complications in different patients, none of which resulting in death. Two patients (2.08 percent) had seroma; hematoma was identified in one patient (1.04 percent); one patient (1.04 percent) had wound infection. Two patients (2.08 percent) had scrotal edema. After a mean follow up of 49.25 months (range 16 to 86.12) two patients (2.08 percent) had chronic pain and one patient (1.04 percent) had hernia recurrence twenty-six months after surgery. CONCLUSION: The repair of inguinal hernia with PHS is a safe, effective and reproducible method, with low complication and recurrence rates or long term symptoms.
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young Adult , Hernia, Inguinal/surgery , Polypropylenes , Surgical Mesh , Equipment Design , Polypropylenes/adverse effects , Postoperative Complications/epidemiology , Retrospective Studies , Surgical Mesh/adverse effects , Surgical Procedures, Operative/adverse effects , Surgical Procedures, Operative/methodsABSTRACT
Os autores fazem uma revisão bibliográfica sobre a síndrome do compartimento abdominal, suas implicações clínicas e fisiológicas, e seu manejo clínico e cirúrgico
Subject(s)
Humans , Male , Female , Abdomen , Compartment Syndromes , Abdominal Injuries , Abdominal Wall/abnormalitiesABSTRACT
Os autores fazem uma revisão bibliográfica sobre o estado atual transplante de pâncreas, de seus aspectos clínico-cirúrgicos, complicações e benefícios desta modalidade de tratamento